NIH R01 · 2024
Macrophages in human autoimmune tissue pathology
In the autoimmune condition rheumatoid arthritis (RA), chronic inflammation reshapes cellular interactions and tissue architecture in patient joints. RA synovium is marked by expanded macrophage and fibroblast populations, extensive lymphocytic infiltration, angiogenesis and, ultimately, outgrowth beyond the natural tissue borders into cartilage and bone. In independent single-cell RNA-sequencing studies, we recently identified a novel macrophage phenotype found enriched in the synovium of RA patients (Zhang et al. Nat Immunol. 2019; Stephenson et al. Nat Comm. 2018). These macrophages express high levels of the EGF receptor (EGFR) ligand HB-EGF and are hereafter referred to as ‘HBEGF+…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.