NIH R01 · 2025
Investigating the role of sleep in synaptic reorganization after neural injury
Project Summary Sleep has been identified as a state of heightened neural plasticity, but the rules that govern reorganization during sleep remain unknown. To better identify the conditions under which synapses are pruned during sleep, we have begun to examine responses to neural injury in the fruit fly. After antennal transection, flies acutely increase their sleep for up to one day before returning back to baseline levels. Our preliminary data also show that pre-synaptic active zones are removed more rapidly than plasma membrane after antennal injury, and that sleep deprivation after injury prevents the clearance of pre-synapses from injured olfactory receptor neurons. In this project, we…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.