NIH R01 · 2025
DNA methylation in kidney repair after ischemic AKI
Acute kidney injury (AKI) is associated with high mortality and increasing prevalence. After AKI, some patients can fully recover but AKI is a risk factor for, and may progress to, chronic kidney disease (CKD). Kidney repair is a key determinant of the outcome or prognosis of AKI survivors. Especially, maladaptive kidney repair after severe or multiple episodes of AKI often leads to chronic renal pathologies characterized by tubular degeneration, chronic inflammation, interstitial fibrosis, and progressive decline of renal function. DNA methylation, catalyzed by DNA methyltransferase (DNMT), is a major epigenetic mechanism in health and disease. However, very few studies examined DNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.