NIH R01 · 2025
Therapeutic effects of APOE regulation via LNP-RNA formulations in Alzheimer's disease
PROJECT SUMMARY Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions worldwide, characterized by memory loss and cognitive decline. The Apolipoprotein E (ApoE) gene is closely linked to AD risk, with APOE4 associated increased susceptibility while APOE2 exhibits protective effects, although the mechanisms of this protection remain poorly understood. Nucleic acid-based therapeutics offer promising avenues for treating AD by targeting pathological genes like APOE and promoting therapeutic protein expression. However, their efficacy is hindered by challenges in crossing the blood-brain barrier (BBB). To address this, we aim to develop novel lipid…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.