NIH R01 · 2024
Genetic dissection of defensin signaling in urinary tract infections
PROJECT SUMMARY Urinary tract infections (UTIs) are commonly caused by uropathogenic Escherichia coli (UPEC) and affect millions of patients, especially elderly women. Antibiotics do not reliably eliminate uropathogens and there is an urgent need for more effective treatments to improve UTI patient outcomes. Thorough understanding of microbe- host interactions in the urinary system will be key to the development of next generation immune therapies. Antimicrobial peptides (AMPs) are a key component of innate immunity, but the functions of these peptides have been very difficult to study due to the lack of animal models. The largest mammalian AMP family, the defensins, has >50 members in…
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