NIH R01 · 2024
HIV interactions with host cell proteins in particle release
Project Summary/Abstract BST-2, also known as tetherin, inhibits HIV-1 release from the plasma membrane of infected cells. HIV-1 Vpu neutralizes this restriction through not-mutually exclusive mechanisms, including degradation/downregulation, sequestration, and displacement. However, the relative importance of each of these anti-tetherin mechanisms in virus replication and transmission remains to be defined. Our long-term goal is to understand the roles of Vpu and tetherin in HIV-1 pathogenesis. Specifically, we aim to understand the mechanisms of how host cell proteins are involved in the Vpu-tetherin interaction. Recent studies from our laboratory demonstrate that a specific host cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.