NIH R01 · 2025
Liver Prlr signaling in metabolic adaptation to pregnancy
Abstract: Pregnancy is characterized by maternal insulin resistance secondary to maternal weight gain, especially in the 3rd trimester. Such physiological response serves to spare blood glucose for the fetus. To compensate for maternal insulin resistance, the body must undergo adaptive changes in energy metabolism to maintain euglycemia during pregnancy. Maladaptation of maternal metabolism to pregnancy is causative for gestational diabetes mellitus (GDM), a disease that affects up to 11% of all pregnancies. Critical for metabolic adaptation to pregnancy is prolactin, a pituitary hormone whose production increases with the progression of pregnancy. Prolactin acts as a lactogenic hormone to…
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