NIH R01 · 2024
Catalytic C−C Activation/Functionalization of Ketones and Amides
Abstract: We are engaged in the systematic efforts to exploit catalytic carbon–carbon (C−C) bond activation for developing new, general and synthetically useful methods. Our objective, in the proposed funding period, is to focus on C−C activation and functionalization of ketones and amides, as they are easily accessible and widely found in feedstock chemicals. Through harnessing the power of transition-metal catalysts, sometimes assisted by an organic activator, a suite of new, selective, and efficient methods involving C−C activation of ketones and amides will be developed. Specifically, we will: (i) explore new C−C activation modes that allow rapid access to complex sp3-rich ring systems,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.