Dong Lab

Research focus

NIH R01 · 2024

The role of extracellular vesicle-associated MicroRNAs in HIV-associated atherosclerosis

People living with HIV (PLWH) have a significantly higher risk of cardiovascular diseases (CVD) compared to their HIV negative counterparts. However, the underlying mechanisms that drive this increased CVD risk remain elusive. Extracellular vesicles (EVs)/exosomes are released by all cells and widely distributed in plasma, urine, and other biological fluids. EVs contain diverse bioactive molecules, including mRNAs, microRNAs (miRs), proteins, and lipids, which can be transferred to target cells altering their functionality. The cargo of EVs reflects the pathophysiological states of the host cells. It is conceivable that the latent HIV reservoir established during early infection, long-term…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.