Donahue Lab

Research focus

NIH R01 · 2024

Translating post-infarct ventricular tachycardia mechanisms into a therapy

ABSTRACT In the United States, several hundred thousand people experience cardiac arrest each year, with the vast majority dying from this condition. Approximately two-thirds of cardiac arrest victims have previously suffered a myocardial infarction (MI), and death results from maladaptive responses to infarct healing. The healed infarct scar creates a substrate that supports malignant ventricular arrhythmias, and death results from ventricular tachycardia (VT) originating in the border zone around the infarct scar. The prevailing paradigm focused on the role of surviving ribbons of myocardial tissue traversing the borderzone region and impaired electrical conduction as components of the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.