NIH R01 · 2024
PROJECT SUMMARY The cellular plasticity of the human pancreas is implied from multiple scRNAseq studies. However, these have been invariably based on static datasets from which fate trajectories can only be inferred using pseudotemporal estimations. Furthermore, the reliance on isolated islet preparations for the conduct of these analyses has resulted in a drastic underrepresentation of other non-endocrine cell types, hindering our ability to accurately interrogate exocrine-endocrine interactions. The long-term culture of human pancreatic slices (HPSs) has presented the field with an opportunity to sidestep these limitations by longitudinally tracking tissue plasticity at the single- cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.