NIH R01 · 2025
Structural-Functional Mechanisms Controlling Actin Filament Barbed and Pointed End Dynamics
Project Summary Actin, which exists in filamentous (F-actin) and monomeric (G-actin) forms, is the most abundant protein in the cytoplasm of eukaryotic cells and a key player in countless processes in health and disease, including cell motility, muscle contraction, cancer metastasis, and cardiomyopathies. F-actin is a polar filament, with fast polymerizing barbed (+) and depolymerizing pointed (-) ends. The control of monomer addition/dissociation at the ends of the actin filament is a key event that affects all cellular functions of actin in health and disease. This process is tightly regulated in cells by actin's ATPase activity and many proteins that control subunit exchange at the ends…
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