NIH R01 · 2025
Role of Alpha Cells in Pathogenesis of Type 1 Diabetes
PROJECT SUMMARY Longitudinal studies have shown that individuals at high genetic risk for type 1 diabetes (T1D) progress through several distinct stages prior to the onset of clinical symptoms. Although the factors causally involved in the rate of progression are poorly understood, the presence of islet autoantibodies (AAb) is currently the best biomarker for the future onset of hyperglycemia in T1D. In particular, the single AAb+ stage (generally against glutamic acid decarboxylase (GADA+)) represents a key window for intervention to delay or prevent progression to T1D. Our recent study on pancreatic islets isolated from GADA+ donors revealed early α-cell dysfunction while β-cell mass and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.