Dolen Lab

Johns Hopkins University

NEUROSCIENCES

Baltimore · United States

NIH-funded
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Research focus

NIH R01 · 2024

Dissecting the role of vasopressin in regulating the critical period for social reward learning

PROJECT SUMMARY: The overall objective of the studies proposed in this revised R01 application is to elucidate the molecular mechanisms underlying regulation of social brain development, a first step in a larger project aimed at identifying circuit based approaches which improve therapeutics for neurodevelopmental disorders characterized by social impairments, as well as diseases which may be the consequence of social injury during brain development. Based on extensive preliminary findings, our overall hypothesis is that developmental upregulation of arginine vasopressin (AVP) signaling constrains social reward learning to a critical period, and that these functions are enabled by…

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