NIH R01 · 2025
ABSTRACT Infants are vulnerable to infection due to their tolerogenic immune phenotype and limited adaptive immune memory, which has limited the success of newborn vaccines. Trans-placental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life. As such, maternal immunization has been implemented as a public health strategy to protect infants against serious infections early in life. The neonatal Fc receptor (FcRn) plays a well- defined role by binding to IgG and transporting it across the placental syncytiotrophoblast to the stroma, which is followed by transport across the fetal capillary endothelium to the fetus, but emerging…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.