NIH R01 · 2025
Understanding the Role of Mechanical Load in Endogenous and Induced Mammalian Digit Regeneration
Project Summary This new RO1 application entitled “Understanding the Role of Mechanical Load in Endogenous and Induced Mammalian Digit Regeneration” is focused on determining how mechanical load regulates various aspects of mammalian appendage regeneration. In the US, one in 190 people is living with limb loss, and that number is projected to double by the year 2050. Present treatments for limb amputation include replantation of amputated parts, revision amputations to accommodate prosthesis fitting, transferring tissue from other locations (e.g. toe-to-thumb transfer), or hand transplantation. These treatments are not without risks and the restoration of normal function is rarely realized.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.