NIH R01 · 2025
Structural Basis for HIV-1 Gag assembly and Env incorporation
During the late phase of HIV-1 infection cycle, the virally encoded Gag polyproteins are targeted to the plasma membrane (PM) for assembly, formation of immature particles, and virus release. Gag–PM binding is mediated by interactions of the N-terminally myristoylated matrix (MA) domain with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Concurrent to Gag assembly, the envelope (Env) protein is recruited to the PM for incorporation into virus particles. Env recruitment, and hence gp41, to a nascent virion is essential for downstream infectivity. Without gp41, there is no fusion and no infectivity. Several lines of evidence suggest that Env incorporation is mediated by interactions…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.