Doerschuk Lab

Research focus

NIH R01 · 2024

Uncovering and understanding the many functions of ICAM-1 in the lungs during homeostasis and innate immune responses

Abstract The gene Icam1 codes for intercellular adhesion molecule-1 (ICAM-1, CD54), a member of the Ig-like superfamily of adhesion proteins and a type 1 membrane-bound glycoprotein. It is expressed constitutively on most lung parenchymal cells, functioning as a receptor for interactions between these parenchymal cells and leukocytes. Its major ligands are the four members of the β2 leukocyte integrin family. Our laboratory has contributed to understanding both the adhesive and the signaling functions of ICAM-1. We identified the differential expression of ICAM-1 on AT1 compared to AT2 cells and its upregulation by lipopolysaccharide and S. pneumoniae on these cells and capillary…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.