NIH R01 · 2025
Solving the puzzle of beta-1,6-glucan in the cryptococcal cell wall
Solving the puzzle of beta-1,6-glucan in the cryptococcal cell wall ABSTRACT Cryptococcus neoformans is a global pathogen responsible for roughly 150,000 deaths each year, mainly in HIV+ individuals but with increasing morbidity in non-AIDS patient populations. Like other fungi, C. neoformans is bounded by a complex and resilient cell wall, which maintains cell integrity while allowing morphologic flexibility. Wall synthesis is a compelling research area, because it is a validated target of antifungal drugs. Unfortunately, these do not work against C. neoformans infection, revealing a pressing need to elucidate the biosynthesis - and potential vulnerabilities - of the cryptococcal wall. Our…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.