NIH R01 · 2025
Microbiota-based probiotics to treat inborn errors in metabolism
Project Summary/Abstract The human gut is a metabolic organ where anaerobic microbial pathways run at high capacity, expanding the biochemical landscape of the human body. Exploiting members of the gut microbiota and the metabolic pathways they encode represents an exciting new strategy to treat genetically encoded biochemical defects in humans such as Phenylketonuria. There are three reasons why identifying new microbiota probiotics should be a priority: 1) Gut microbes represent an important yet untapped resource for new metabolic pathways that influence human biochemistry. 2) Microbiota pathways are present in healthy individuals, and their metabolic end products are unlikely to be toxic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.