NIH R01 · 2024
PROJECT SUMMARY. Recent epidemiological reports indicate that cocaine use increased by 45% from 2013 to 2018. Cocaine-induced increase in striatal dopamine levels is linked to its rewarding effects. However, the striatal neural circuits driving cocaine abuse are not clearly defined. Thus, there is a critical need to delin- eate how the striatal circuits downstream of cocaine-induced dopamine release control cocaine seeking and taking. The overall objective of this proposal is to determine the mechanisms by which cocaine affects GABA transmission between the two principal neurons of the striatum, the D1-MSNs and D2-MSNs, to ultimately regulate drug seeking and taking. Our central hypothesis…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.