NIH R01 · 2024
Corticothalamic circuits mediating behavioral adaptations to unexpected reward omission
PROJECT SUMMARY/ABSTRACT Environmental cues that are associated with food develop attractive and motivational properties that elicit reward-seeking behaviors in animals. However, when food-associated cues no longer lead to rewards, animals quickly adjust their behaviors by showing a transient increase of reward-seeking responses (invigoration) and a set of behavioral responses that resemble frustrative behaviors in humans. Repeated exposure to reward omission leads to behavioral attenuation that serves to suppress unproductive appetitive responses. Although significant progress has been made in elucidating the brain structures that regulate the acquisition and the extinction of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.