NIH R01 · 2024
Cell-derived therapies for corneal nerve repair: Structural and functional mechanisms
PROJECT SUMMARY Injured corneal nerves can regenerate but in general, the resulting nerve repair is incomplete or may take years to recover their original density and patterning. While several growth factors can enhance the recovery of damaged corneal nerves and one of them has been clinically approved to treat corneal injuries (nerve growth factor), patients still complain about discomfort, dryness, and pain. These observations indicate that more complete anatomical and sensory regeneration of injured nerves may need to occur for patients to recover. Most likely the type/site/time of nerve injury affects the anatomical, molecular, and functional regeneration of corneal nerves. Therefore,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.