NIH R01 · 2024
Regulation of Cyclic GMP Synthesis in Photoreceptors
PROJECT SUMMARY Cyclic cGMP (cGMP) enables phototransduction in vertebrate rods and cones. The cGMP synthesis by retinal guanylyl (guanylate) cyclase (RetGC), one of the most essential processes in the photoreceptor physiology, is controlled by calcium, guanylyl cyclase activating proteins (GCAPs), and retinal degeneration 3 (RD3) protein. The abnormalities in cGMP signaling cause photoreceptor dysfunction and death. Among them, deficiency in RetGC activity and regulation leads to a variety of recessive and dominant forms of congenital blindness. The basic principles of the RetGC regulation and its fundamental importance for the photoreceptor signaling and survival have been established,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.