NIH R01 · 2025
Molecular choreography and trafficking in the aging myocardium
Project Summary Aging is an independent risk factor for cardiovascular disease and with an aging global population there is an urgent need to increase health-span alongside the already increased lifespan, allowing people to live independent and healthy lives well into their old age. Cardiac aging is inevitably accompanied by a progressive deterioration in cardiac function, including loss of responsivity to β-adrenergic receptor signaling and impaired myocardial relaxation resulting in diastolic dysfunction but the molecular mechanisms that drive these functional deficits are not understood. Recent progress has identified prominent signs of endosomal pathway dysfunction in ventricular…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.