NIH R01 · 2024
Impact of dysbiosis on the development of age-related inflammation
PROJECT SUMMARY The “pillars of aging” hypothesis entails that chronic unresolved inflammation, coupled with metabolic dysfunction and macromolecular damage are among the key mechanisms that impairs cellular renewal and regenerative processes that contribute to aging and chronic diseases. Inflammation is a protective mechanism that has evolved to protect against pathogens and tissue injury that enables a host to survive life-threatening challenges by restoration of homeostasis. How then does a protective response like inflammation become chronic, drive aging and serve as a trigger of chronic disease? In absence of overt infections in aging, alterations in the gut microbiota (dysbiosis) or…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.