NIH R01 · 2024
Mitophagy and Cardiac Myocyte Protein Aggregation
Cardiac myocyte protein quality control is critical for maintenance of the contractile apparatus and cardiac function. Mutations in chaperone proteins that affect protein quality control induce proteotoxicity, sarcomere dysfunction and cardiac myocyte cell death. One such point mutation in the CRYAB gene in humans, results in an arginine to glycine change at position 120 in the heat-shock protein beta-5 (R120G HSPB5) protein, and provokes autosomal dominant cardiomyopathy resulting in heart failure, need for cardiac transplantation and premature mortality. Strategies to prevent proteotoxicity have focused on stimulating the autophagy-lysosome pathway to remove protein aggregates; and need…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.