NIH R01 · 2024
Interrogating Clonal Repertoire in Drug Hypersensitivity Reactions
Project Summary Delayed-type drug hypersensitivity reactions (dtDHR) are a major yet underappreciated public health problem, occurring commonly in skin-limited form, morbilliform drug eruption (MDE), and causing significant morbidity and mortality in severe systemic forms, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). dtDHR are significantly understudied. Consequently, understanding of immunopathogenesis has been limited, and subsequent to that, so too clinical care. Two major clinical limitations are the lack of a reliable laboratory test to identify culprit drug and an inability to accurately screen…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.