Dittmer Lab

Univ of North Carolina Chapel Hill

MICROBIOLOGY/IMMUN/VIROLOGY

Chapel Hill · United States

NIH-funded
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NIH R01 · 2025

Replication studies for Kaposi Sarcoma mice

PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-RM- 24-013. Angiogenesis is central to cancer development; together with Angiosarcoma and Hemangioma, Kaposi Sarcoma (KS) is the most angiogenic cancer in humans. KS is the most common cancer in people living with HIV worldwide. In the USA today, KS is concentrated in underrepresented minorities (URM) of black race or Hispanic ethnicity as well as in underserved and marginalized populations. The current frontline regimen for KS was developed in the 1980s. Despite its discovery over 25 years ago, no proper, immune-competent animal model existed for KS or…

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