NIH R01 · 2024
Improvement of cellular immunotherapy during dysbiosis - A. A. Brint Supplement
Project Summary The use of antibiotics has significantly increased in recent years. Antibiotics (ABX) severely alter the gut microbiome, destroying potentially pathogenic bacteria, as well as beneficial ones—producing a state of microbial imbalance called dysbiosis. Notably, a diminished gut microbiome has severe defects on the immune system, yet how these defects may affect cellular immunotherapy is largely unknown. To better understand how dysbiosis influences cellular immunotherapy, we focused on melanoma as an exemplary immunogenic solid tumor. The incidence of melanoma has increased drastically over the past decades, with its morbidity rate continuing to outpace that of most other…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.