NIH R01 · 2025
Functional Connectome of Brain White Matter
ABSTRACT / SUMMARY The goals of this research are to extend our discoveries of how blood oxygenation level dependent (BOLD) signals in white matter (WM), detected using functional magnetic resonance imaging (fMRI), are related to neural activity in gray matter (GM), and to implement new analyses that properly incorporate WM signals into models of brain function derived from imaging data. For the past three decades, nearly all analyses of brain fMRI data have ignored WM signals and usually have removed them as nuisance regressors. However, that view has changed in light of more recent evidence that WM BOLD signals represent potentially important and heretofore overlooked indicators of neural…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.