NIH R01 · 2025
Volumetric imaging and computation to characterize cardiac electromechanical coupling
PROJECT SUMMARY / ABSTRACT Volumetric imaging and computation to characterize cardiac electromechanical coupling Approximately 450,000 individuals in the United States die suddenly from cardiac arrhythmias every year. Many widely used medications such as antiarrhythmic agents, antimicrobials, anticancer drugs, and psychotropic drugs can cause or exacerbate a variety of arrhythmias. However, the fundamental mechanisms of most clinical arrhythmias remain poorly understood. The ability to prospectively identify potentially arrhythmogenic compounds would be clinically valuable. Recent advances demonstrate that zebrafish are a productive model system to screen small molecules that function as…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.