NIH R01 · 2025
Develop a novel multi-approach dynamic Spot Scanning Proton Arc optimization framework
Project Summary Spot-scanning Proton Arc (SPArc) therapy is an emerging treatment modality that has shown potential clinical benefits for a wide range of disease sites. Unlike the conventional step-and-shoot multi-field Intensity Modulated Proton Therapy (IMPT), SPArc therapy utilizes arc trajectories for planning and treatment. The extra degree of freedom offers superior dose conformity which is particularly crucial for treating head and neck squamous cell carcinoma (HNSCC) patients, where organs-at-risk (OARs) are often adjacent to the target volume. Therefore, sharp dose fall-off using SPArc therapy is able to reduce radiation-induced toxicity. In 2018, the concept of SPArc therapy was…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.