NIH R01 · 2025
Project Summary Focal ischemic ischemia (FCI) is a leading cause of human death, however, functional recovery after FCI has been observed and can be remarkable in both patients and animal models. Due to limited therapeutic choices for clinical treatment, studying its mechanisms has been an important topic and could provide therapeutic insights. Astrocytes in normal adult brains referred to as resting astrocytes (RestAs) are quiescent, but they undergo rapid proliferation, display a `hypertrophic' morphology, exhibit an altered transcriptional profile, and eventually form glial scars in the peri-infarct region (PIR) after FCI. These phenomena are known as reactive astrogliosis, and the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.