NIH R01 · 2025
Epitranscriptomic regulation in hematopoietic stem cell niche generation and regeneration
Project summary/Abstract Hematopoietic stem cells (HSCs) rely on the bone marrow niche. Understanding HSC niche generation during development and regeneration after injury will help devise ways to promote HSC function and hematopoiesis. During development, HSCs take residence in the newly established bone marrow niche and remain there for the rest of the adult life. After injury, the bone marrow niche can regenerate to support the recovery of HSCs and hematopoiesis. Mesenchymal stromal cells (MSCs) are key components of the bone marrow HSC niche. However, the mechanisms that regulate the generation and regeneration of the bone marrow MSCs and HSC niche are poorly understood. N6-…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.