NIH R01 · 2025
Post-TB epigenetic scars' impact on long-term inflammation, immunity and mortality
PROJECT SUMMARY: After apparently successful treatment, Tuberculosis (TB) survivors have a 16.9% of death, a rate 3-fold higher than age and sex matched controls. In our previous work, we identified that six months after the completion of successful TB therapy, survivors retained detrimental epigenetic scars that continue to perturb host immunity and inflammation. In this proposal, using currently enrolling cohorts, we will test our proposal that these detrimental epigenetic scars induce pathologic inflammation and decrease immune responsiveness, leading to increased risk of post-TB mortality. Our previous work demonstrated that TB induces more than a thousand DNA methylation perturbations…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.