NIH R01 · 2025
Protein structure determination from low-resolution experimental data
Abstract Determination of a protein’s three-dimensional structure is of critical importance in biology, providing insights to biological mechanisms and important targets for drug design. While high- resolution X-ray diffraction data provides an atomic view of cellular components, for many interesting and biologically relevant complexes, it may only be possible to obtain low-resolution structural information. In recent years, cryo-electron microscopy (cryo-EM) has emerged as a powerful method to gain structural insights into these large molecular machines. However, for many complexes of interest, data is often: a) extremely limited in resolution, lacking atomic details, and b) highly…
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