NIH R01 · 2024
The "dark immunopeptidome" as a source of CD8 T cell epitopes in type 1 diabetes
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. T cell responses to the beta cell autoantigen insulin are essential for efficient development of type 1 diabetes (T1D). An important emerging concept related to the essential nature of insulin as an autoantigen is that CD4+ T cell responses develop to unconventional insulin peptides, including hybrid peptides in which amino acids from insulin are linked to those from another protein (or another region of insulin). In the case of beta cell- cytotoxic CD8+ T cells, which are essential for beta cell killing, little is known about their ability to recognize…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.