NIH R01 · 2025
From Manic Symptoms to Bipolar Disorder: Neural-behavioral Markers Using Two Analytic Models
PROJECT SUMMARY -No change from the original submission Bipolar disorder (BD) is a devastating neuropsychiatric illness that affects 2-5% of youth and causes morbidity, functional impairment, and suicide. Prodromal manic symptoms without manic episodes usually emerge before BD types I and II (BD-I/II) develop, but less than 60% of youth with manic symptoms will develop BD-I/II. The uncertainty of diagnosis and illness progression results in potentially detrimental interventions and 7-10 years delay appropriate treatments. It is thus imperative that objective biomarkers of risk for conversion to BD-I/II are identified and tested in youth before the peak onset of illness. Given that neural…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.