NIH R01 · 2024
Examining the role of the miR-181a:Wnt/B-catenin axis in ovarian cancer
Project Summary/Abstract High grade serous carcinoma (HGSC) the most common type of “ovarian” cancer is one of the deadliest cancers diagnosed in women. One of the primary drivers for the high mortality rate associated with HGSC is tumor recurrence and chemoresistance. Thus, there is a critical need to identify the genetic drivers of tumor development and recurrence to improve therapeutic strategies. In this proposal, we provide extensive evidence for the clinical and biological importance of miR181a, which is amplified in a large majority of HGSC patients, correlates with poor overall survival, and induces epithelial to mesenchymal transition (EMT), metastasis, drug resistance, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.