NIH R01 · 2025
PROJECT SUMMARY Bacterial infections constitute a major burden on healthcare systems globally. One of the reasons these diseases are difficult to treat is that most antibiotics act specifically on rapidly growing cells, but bacteria in many types of infections grow slowly and exist in static aggregates. Our long-term goal is to define the integrated molecular pathways that support survival of bacteria in aggregates that contain chemical gradients, with a focus on the opportunistic pathogen Pseudomonas aeruginosa. To investigate multicellular physiology and spatial organization, we employ standardized models in which aggregates are grown suspended in a supplied polymer matrix, or at…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.