NIH R01 · 2024
Role of DNA damage and cellular senescence in osteoarthritis pathophysiology
PROJECT SUMMARY A key priority for the NIH is to limit disability caused by osteoarthritis (OA) and other chronic diseases that emerge with age. Senescent cells within joint tissues contribute to OA, but there is a knowledge gap regarding the triggers by which decades of aging initiate cellular senescence. One key mediator of senescence in other contexts is persistent DNA damage and the subsequent activation of a set of signaling pathways known as the DNA damage response (DDR). The DDR can drive the production of inflammatory and matrix-degrading molecules collectively known as the senescence-associated secretory phenotype (SASP), which has strong overlap with catabolic molecules known to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.