NIH R01 · 2025
Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions
Project Summary The microbiota provides many key signals that support development and functioning of the immune system. Interactions between host and microbiota allows for proper induction of immune responses against pathogens. These interactions are also necessary to limit inflammatory immune responses against the microbiota which, if left unchecked, will result in inflammatory conditions including inflammatory bowel disease. Many intestinal cell types including immune cells and the intestinal epithelium recognize and respond to the microbiota. It is unclear how such signals are integrated to support homeostasis. In humans as well as in animal models of disease, compositional changes in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.