NIH R01 · 2025
TNF alpha and Recovery from Alcoholic Liver Injury
Morbidity and mortality in alcohol-related liver diseases (ALD) are caused by severe alcohol-induced steatohepatitis (SAH) and cirrhosis (AC). Effective therapies are lacking because the mechanisms driving the pathogenesis and progression of SAH and AC are unclear. This research program has evaluated the general hypothesis that bad outcomes of alcohol-induced liver injury result from deregulated repair mechanisms that cause defective regeneration of mature hepatocytes. Our prior results indicate that effective liver regeneration requires reactivating fetal programs to nurture the outgrowth of liver progenitors but then silencing these programs, so the liver matures appropriately. Thus, we…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.