Arai Lab

Research focus

NIH R01 · 2025

Assessing myocardial fibrosis with spin locked MRI

Summary Myocardial fibrosis serves to define various cardiac diseases, and is very useful as an early marker of cardiovascular disease and its progression. Some myocardial fibrosis is reversible and can be surveilled to determine response to treatment. Late gadolinium enhancement (LGE) MRI is a robust method for sizing scar (focal fibrosis) regions. Diffuse fibrosis and hemorrhagic infarctions can be more difficult to assess well. A relatively new MRI method, spin locking or T1rho imaging, is thought to provide valuable information regarding myocardial fibrosis. However, many problems including a variety of implementations with wide-ranging T1rho values, challenging artifacts, possibly…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.