NIH R01 · 2025
Regulation and Requirements for Coenzyme A Biosynthesis
SUMMARY Metabolic dysfunction-associated fatty liver disease and chronic kidney disease, affecting tens of millions of people in the US alone, exhibit pathological dysregulation of lipid metabolism which is heavily dependent on the pivotal cofactor Coenzyme A (CoA). Yet, we do not fully understand how cells and tissues regulate and coordinate the biosynthesis of CoA with the demands of CoA-dependent metabolism, biosynthesis, and homeostasis (e.g. of lipids); nor how CoA synthesis dysregulation and disease progression are related in the kidney and liver. As the major carrier of activated acyl groups, CoA is required for the TCA cycle, lipid synthesis, and fatty acid oxidation among other…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.