Diaz Lab

Brigham and Women's Hospital

Boston · United States

NIH-funded
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NIH R01 · 2025

Clinical implications and Proteomics of Bronchiectasis Progression in Smokers

Project Summary/Abstract Individuals with coexisting COPD and bronchiectasis have worse lung function, longer hospital stays, and an increased risk of death. Bronchiectasis, a pathologic airway enlargement, is increasingly recognized in the US, with 522,000 adults treated annually for bronchiectasis. Bronchiectasis is also a relevant abnormality in chronic obstructive pulmonary disease (COPD), affecting up to 72% of these individuals. While the development of advanced imaging methods has facilitated our understanding of COPD progression, a critical factor hampering our ability to examine bronchiectasis progression fully is the lack of an objective imaging tool applicable in large studies.…

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