NIH R01 · 2024
Late-Stage Modification of Biomolecules via Radical-Based Methods
Project Summary Late-stage modification of pharmaceutically relevant small molecules and biomolecules, including alcohols, peptides, and carbohydrates, is crucial in drug discovery and chemical biology research. However, achieving selectivity and specificity among the diverse functional groups present within such molecules is a primary challenge in late-stage functionalization. This proposal aims to address this challenge by leveraging the non- polar nature of radical intermediates, which exhibit orthogonal reactivity compared to the prevalent polar functional groups found in biomolecules. Specifically, a phosphoramidite reagent will selectively functionalize hydroxyl groups by enabling…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.