NIH R01 · 2024
The role of VAMP2 in alpha-synuclein function and pathology
PROJECT SUMMARY α-Synuclein (α-Syn) is a protein abundantly distributed in presynaptic terminals. α-Syn pathology is linked to synucleinopathies including Parkinson’s disease (PD) and Lewy body dementia, and α-Syn missense muta- tions cause early onset PD. Physiologically, α-Syn functions in synaptic transmission via clustering synaptic vesicles (SVs) and promoting SNARE-complex assembly. This function strongly depends on binding to SVs. Pathologically, levels of vesicle-associated membrane protein 2 (VAMP2) and functional monomeric α-Syn simultaneously decrease with increasing duration of dementia, which implies a potential functional link between VAMP2 and normal monomeric α-Syn.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.