NIH R01 · 2024
Clinical Translation of a Large Oncosome-Based Prostate Cancer Blood Test
ABSTRACT - The focus of this proposal is on lethal, metastatic prostate cancer (PC). The aim of this study is to develop an innovative, minimally invasive, liquid biopsy assay that can be used to identify molecular subtypes of lethal prostate cancer PC in patients with a biologically aggressive disease. Phenotyping Large Oncosomes for Ultimate Evaluation of Patients Status (PLUS) will identify biomarkers of short/long response to treatment, and progressively assess tumor phenotype during PC evolution and under treatment pressure. We propose to focus on extracellular vesicles (EV) known as large oncosomes (LO) that are identified in the plasma of patients with aggressive cancer. Using gold…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.